• Plasmid-associated antimicrobial resistance and virulence genes in Escherichia coli in a high arctic reindeer subspecies 

      Sunde, Marianne; Ramstad, Silje N.; Rudi, Knut; Porcellato, Davide; Ravi, Anuradha; Ludvigsen, Jane; das Neves, Carlos Gonçalo; Tryland, Morten; Ropstad, Erik; Slettemeås, Jannice S.; Telke, Amar A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-30)
      Objectives - In extreme environments, such as the Arctic region, the anthropogenic influence is low and the presence of antimicrobial-resistant bacteria is unexpected. In this study, we screened wild reindeer (Rangifer tarandus platyrhynchus) from the Svalbard High Arctic Archipelago for antimicrobial-resistant Escherichia coli and performed in-depth strain characterisation.<p> <p>Methods - Using ...
    • Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations 

      Flatby, Helene Marie; Rasheed, Humaira; Ravi, Anuradha; Thomas, Laurent; Liyanarachi, Kristin Vardheim; Afset, Jan Egil; DeWan, Andrew; Brumpton, Ben Michael; Hveem, Kristian; Åsvold, Bjørn Olav; Simonsen, Gunnar Skov; Furberg, Anne-Sofie; Damås, Jan Kristian; Solligård, Erik; Rogne, Tormod (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-09)
      Objective: Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality worldwide. Few studies have previously investigated the genetic susceptibility and potential risk factors for LRTI. Methods: We used data from UK Biobank, HUNT, and FinnGen, to conduct a genome-wide association study (GWAS). Cases were subjects hospitalized with LRTI, and controls were subjects with ...